Dr. Alexander and Drew Doering publish a paper on a new genome editing tool.
Drew Doering wins Poster Award at UW Genetics Retreat!
Christina Kuang and Drew Doering win CMB Travel Awards!
Chris Todd Hittinger, Cletus P. Kurtzman, and Antonis Rokas have been awarded a Dimensions of Biodiversity grant from the National Science Foundation!
Dr. William Alexander, Drew T. Doering, and Chris Hittinger publish a new method for efficient genome editing and allele replacement in wild and industrial yeasts!
Chris Hittinger is named a Pew Scholar in the Biomedical Sciences
The lab welcomes Michael Price and Sarah Wright, summer student and teacher, and we say goodbye to Qi-Ming Wang.
Drew Doering wins GSTP traineeship.
~ April 9, 2014 ~
David Peris and collaborators' research into Saccharomyces eubayanus diversity appears on the cover of Molecular Ecology!
WildYEAST program debuts at Wisconsin Science Festival.
Ryan Moriarty joins the WildYEAST program. Happy Hunting!
Quinn Langdon begins her NSF Graduate Research Fellowship.
New Lab Members:
First Wild YEAST Program
Chris Hittinger presents at "Wednesday Night at the Lab"
Lager yeast origins discovered
The Hittinger Lab uses yeast carbon metabolism as a model for basic bioenergy, biomedical, and evolutionary research. Our research interests and integrated approaches are at the intersection of biodiversity; biochemistry; biotechnology; and functional, ecological, and evolutionary genomics. Ongoing projects are focused on understanding the origin and evolution of aerobic fermentation, yeast ecology and biodiversity, genetic variation in natural and industrial yeasts, genome engineering and synthetic biology, and the metabolism of alternative carbon sources (e.g. galactose, maltose, xylose) that may have bioenergy and brewing applications.
Dr. William Alexander and Drew Doering publish a paper on genome editing...
High-efficiency genome editing and allele replacement in prototrophic and wild strains of Saccharomyces.
Drew Doering wins the UW Genetics Retreat Poster Award for early-years PhD Candidates! Congratulations, Drew!
Christina Kuang and Drew Doering win CMB Travel Awards! Congratulations Christina and Drew!
Chris Todd Hittinger, Cletus P. Kurtzman, and Antonis Rokas have been awarded a Dimensions of Biodiversity grant from the National Science Foundation! "The Making of Biodiversity Across the Yeast Subphylum" or Y1000+ Project will sequence the complete genomes of all ~1000 described species of Saccharomycotina yeasts and explore how genetic and ecological diversity have evolved across hundreds of millions of years. Apply now to join the project as a postdoctoral researcher or student!
William G. Alexander, Drew T. Doering, and Chris Todd Hittinger publish a new method for efficient genome editing and allele replacement in wild and industrial yeasts! The accepted version of the paper appears online in Genetics . The Haploid Engineering and Replacement Protocol (HERP) cassettes are available (email), along with detailed protocols describing their use.
The Hittinger Lab welcomes Michael Price, REU, and Sarah Wright, RET, to the lab for summer experiments and learning!
We also wish Qi-Ming Wang, visitor from the Bai Lab in China, the best for the rest of his career!
Drew Doering, PhD candidate, has won a Genomic Sciences Training Program traineeship based on his project "Mapping functional consequences of sequence divergence in yeast and beyond via pooled allele swapping". To see more about GSTP, please continue here.
~ April 9, 2014 ~
David Peris and collaborators' research into Saccharomyces eubayanus diversity appears on the cover of Molecular Ecology! This new work shows that S. eubayanus, one of the parents of hybrid lager-brewing yeast, is native but not endemic to Patagonia. Diego Libkind isolated highly diverse strains in Patagonia, but Kayla Sylvester isolated rare strains in Wisconsin. These are the first pure S. eubayanus strains isolated from outside of South America, and their low diversity and mosaic genetic makeup suggest that they are recent migrants. In contrast with Patagonian S. eubayanus, we show that hybrid European brewing strains have very low diversity. Read the UW press release here.
The S. eubayanus strains from Wisconsin are available for licensing. Click here for information.
Drew Doering joins the lab!
Mariana Lopes, a PhD candidate from Brazil, joins the lab! We are excited to have her with us for 1 year.
Wild YEAST program debuts at Wisconsin Science Festival September 29. Check us out!
Ryan Moriarty joins the Hittinger Lab as a Freshman Undergraduate Research Student in the WildYEAST program. Happy Yeast Hunting!!!
Quinn Langdon begins her NSF Graduate Research Fellowship on the "Ecological genomics of temperature preference in wild S. eubayanus yeast." Congratulations to Quinn on winning this prestigious fellowship!
"Chris Todd Hittinger, an assistant professor of genetics and a researcher with the Great Lakes Bioenergy Research Center (GLBRC), has won a National Science Foundation Faculty Early Career Development (CAREER) award to study how Saccharomyces yeasts...(read more)"
The WildYEAST program celebrates its second summer of research with two undergraduate researchers.
New Lab Members:
The Hittinger Lab hosts the first summer participants in the Wild YEAST Program. Participants take part in hands-on wild yeast isolation to identification, and beyond! Click on the logo above to learn more.
8th - Chris Hittinger presents The Origin and Evolution of Lager-brewing Yeast: Hunting Wild Yeast in Patagonia and Around the World. Click here to watch.
Kayla Sylvester joins the lab
Meihua (Christina) Kuang joins the lab
Brielle James joins the lab
Our tri-continental collaboration reports the discovery of the missing contributor to hybrid lager yeast strains in the Proceedings of the National Academy of Sciences of the USA. This newly discovered species hybridized with a Saccharomyces cerevisiae ale yeast to form the lager yeast Saccharomyces pastorianus. Named Saccharomyces eubayanus for its relationship to the complex hybrid Saccharomyces bayanus, it thrives in the cool environment of Patagonia on southern beech trees and their sugar-rich galls (see pictures on this page and more here). Click here for a general summary from the UW press office. Click here for the genome sequence data. Click here to download the paper. (Photos by Diego Libkind)
Dr. William G. Alexander joins the lab as our first postdoc!
Hittinger Lab opens!
Our 6-lab Saccharomyces sensu stricto (SSS) consortium releases vastly improved complete genome sequences and a collection of genetically engineered lab strains for 3 species of yeast. The work is described in the inaugural issue of the new Genetics Society of America (GSA) open-access journal G3: Genes | Genomes | Genetics. Click here to download the paper. Click here to view all the supplements and browsers. Click here to request strains.
Photo by Diego Libkind
Chris Todd Hittinger
Laboratory of Genetics
425-G Henry Mall
2434 Genetics/Biotechnology Center
Madison, Wisconsin 53706-1580
Contact the Lab: HittingerLab at genetics(dot) wisc(dot)edu UW Directory Link