TheHittingerLab

TheHittingerLab

The Hittinger Lab

Beer Montage

The Hittinger Lab uses yeast carbon metabolism as a model for basic bioenergy, biomedical, and evolutionary research. Our research interests and integrated approaches are at the intersection of biodiversity; biochemistry; biotechnology; and functional, ecological, and evolutionary genomics. Ongoing projects are focused on understanding the origin and evolution of aerobic fermentation, yeast ecology and biodiversity, genetic variation in natural and industrial yeasts, genome engineering and synthetic biology, and the metabolism of alternative carbon sources (e.g. galactose, maltose, xylose) that may have bioenergy and brewing applications.

LAB NEWS

~ September 10, 2014 ~

Chris Todd Hittinger, Cletus P. Kurtzman, and Antonis Rokas have been awarded a Dimensions of Biodiversity grant from the National Science Foundation! "The Making of Biodiversity Across the Yeast Subphylum" or Y1000+ Project will sequence the complete genomes of all ~1000 described species of Saccharomycotina yeasts and explore how genetic and ecological diversity have evolved across hundreds of millions of years. Apply now to join the project as a postdoctoral researcher or student!

~ September 9, 2014 ~

William G. Alexander, Drew T. Doering, and Chris Todd Hittinger publish a new method for efficient genome editing and allele replacement in wild and industrial yeasts! The accepted version of the paper appears online in Genetics . The Haploid Engineering and Replacement Protocol (HERP) cassettes are available (email), along with detailed protocols describing their use.

~ June 24, 2014 ~

Chris Hittinger is named a Pew Scholar in the Biomedical Sciences. Please see the press releases by the Pew Charitable Trusts and University of Wisconsin for more information.

~ June 2014 ~

The Hittinger Lab welcomes Michael Price, REU, and Sarah Wright, RET, to the lab for summer experiments and learning!

We also wish Qi-Ming Wang, visitor from the Bai Lab in China, the best for the rest of his career!

~ May 2014 ~

Drew Doering, PhD candidate, has won a Genomic Sciences Training Program traineeship based on his project "Mapping functional consequences of sequence divergence in yeast and beyond via pooled allele swapping". To see more about GSTP, please continue here.

~ April 9, 2014 ~

Beer MontageDavid Peris and collaborators' research into Saccharomyces eubayanus diversity appears on the cover of Molecular Ecology! This new work shows that S. eubayanus, one of the parents of hybrid lager-brewing yeast, is native but not endemic to Patagonia. Diego Libkind isolated highly diverse strains in Patagonia, but Kayla Sylvester isolated rare strains in Wisconsin. These are the first pure S. eubayanus strains isolated from outside of South America, and their low diversity and mosaic genetic makeup suggest that they are recent migrants. In contrast with Patagonian S. eubayanus, we show that hybrid European brewing strains have very low diversity. Read the UW press release here.

Download the paper here.

Supplemental data is found here.

Or request a copy.

The S. eubayanus strains from Wisconsin are available for licensing. Click here for information.

~ December 2013~

Drew Doering joins the lab!

~ November 2013~

Mariana Lopes, a PhD candidate from Brazil, joins the lab! We are excited to have her with us for 1 year.

~ September 2013~

Wild YEAST program debuts at Wisconsin Science Festival September 29. Check us out!

Ryan Moriarty joins the Hittinger Lab as a Freshman Undergraduate Research Student in the WildYEAST program. Happy Yeast Hunting!!!

~ August 2013~

Quinn Langdon begins her NSF Graduate Research Fellowship on the "Ecological genomics of temperature preference in wild S. eubayanus yeast." Congratulations to Quinn on winning this prestigious fellowship!

~ Summer 2013~

"Chris Todd Hittinger, an assistant professor of genetics and a researcher with the Great Lakes Bioenergy Research Center (GLBRC), has won a National Science Foundation Faculty Early Career Development (CAREER) award to study how Saccharomyces yeasts...(read more)"

Qi-Ming Wang, a Senior Scientist from China, joins the lab! We are excited to have him learning with us for one year.Cover of Trends in Genetics

Our review on Saccharomyces diversity appears on the cover of "Trends in Genetics", May 2013

The WildYEAST program celebrates its second summer of research with two undergraduate researchers.

~ Winter 2012 ~

Emily Baker and Heidi tessmer join the lab!

~ Fall 2012 ~

New Lab Members:

Jin Kang
Russell Mendez
D. Peris Navarro, PhD

GallGroup

~ Summer 2012 ~

The Hittinger Lab hosts the first summer participants in the Wild YEAST Program. Participants take part in hands-on wild yeast isolation to identification, and beyond! Click on the logo above to learn more.

~ February 2012~

8th - Chris Hittinger presents The Origin and Evolution of Lager-brewing Yeast: Hunting Wild Yeast in Patagonia and Around the World. Click here to watch.

~ January 2012~

Kayla Sylvester joins the lab

~ December 2011~

Meihua (Christina) Kuang joins the lab

~ September 2011~

Brielle James joins the lab

GallGroup

~ 22 August 2011 ~

Our tri-continental collaboration reports the discovery of the missing contributor to hybrid lager yeast strains in the Proceedings of the National Academy of Sciences of the USA. This newly discovered species hybridized with a Saccharomyces cerevisiae ale yeast to form the lager yeast Saccharomyces pastorianus. Named Saccharomyces eubayanus for its relationship to the complex hybrid Saccharomyces bayanus, it thrives in the cool environment of Patagonia on southern beech trees and their sugar-rich galls (see pictures on this page and more here). Click here for a general summary from the UW press office. Click here for the genome sequence data. Click here to download the paper. (Photos by Diego Libkind)

~ 1 August 2011 ~

Dr. William G. Alexander joins the lab as our first postdoc!

~ 1 July 2011 ~

Hittinger Lab opens!

~ April-June 2011 ~Gall

Our 6-lab Saccharomyces sensu stricto (SSS) consortium releases vastly improved complete genome sequences and a collection of genetically engineered lab strains for 3 species of yeast. The work is described in the inaugural issue of the new Genetics Society of America (GSA) open-access journal G3: Genes | Genomes | Genetics. Click here to download the paper. Click here to view all the supplements and browsers. Click here to request strains.

 

Photo by Diego Libkind

CONTACT INFORMATION:

Chris Todd Hittinger
Laboratory of Genetics
425-G Henry Mall
2434 Genetics/Biotechnology Center
Madison, Wisconsin 53706-1580
United States

Contact the Lab: HittingerLab at genetics(dot) wisc(dot)edu UW Directory Link


©2008-2014 by Chris Todd Hittinger